We found that VACV-β-gal infection of MHC I KO→B6 mice resulted in an anti-TSYKFESV response in the spleen that was very reduced as compared to B6→B6 controls (Figure 2B), confirming our previous work [6] demonstrating that BMD APC are essential for the anti-VACV TCD8+. The gene discussed is PPIB; the disease is infection.