In murine studies the catabolic effect of TNF on muscle was found to be mediated by MIF [37], as the administration of an anti-MIF antibody was found to abolish the TNF-induced hypoglycemia and the increase in muscle F2, 6 BP levels, which is a powerful allosteric regulator of glycolysis and lactate production. The gene discussed is TNF; the disease is Hypoglycemia.