MIF and type 2 diabetes mellitus: The stimulating effect of MIF on the expression of T2D risk factors (e.g., CRP) appears to reside within the protein's conformationally sensitive catalytic domain(s) [48] because protein mutants of MIF which lack the intrinsic oxidoreductase or tautomerase activity [49–51] also did not stimulate human CRP expression in CRP transgenic mice [42].