LCP1 and breast carcinoma: Furthermore, treatment of MCF-7 breast cancer cells with the cell invasion promoting agent phorbol 12-myristate 13-acetate (PMA), triggered the translocation of endogenous L-plastin to ruffling membranes and spike-like structures as well as L-plastin Ser5 phosphorylation, through activation of PKC-δ signaling pathways.