Fountzilas et al. analyzed retrospectively 37 patients with locally advanced HNSCC treated with concomitant radiotherapy, weekly cisplatin, and cetuximab for a series of biomarkers (tumor EGFR, MET, ERCC1, and p-53 protein and/or gene expression, MMP9 mRNA) and correlated those with treatment response. The gene discussed is EGFR; the disease is head and neck squamous cell carcinoma.