Numerous clinical observations show that VDR activation therapy was associated with a survival benefit in CKD patients with an effectiveness order of: paricalcitol > calcitriol > no VDR activation therapy, independent of the parathyroid hormone (PTH) and calcium levels; the survival benefit of VDR activation agents is likely associated with a decrease in cardiovascular-related mortality [14–18]. Here, PTH is linked to chronic kidney disease.