In line with our patient data and in line with various other murine models of sepsis induced by LPS, E. coli or CLP [4],[16],[46], we observed a strong upregulation of MIF expression in both the lungs and blood of mice inoculated with B. pseudomallei. However, MIF seems to play a less important role in the innate immune response in melioidosis, which is in contrast with previous studies pointing towards a central role of MIF in other forms of infection. The gene discussed is MIF; the disease is infection.