Mice administered anti-DV1 serum and challenged with DV2 D2S10 also experienced significant increases in serum TNF-α (p<0.01) and IL-10 (p<0.01) and greater platelet depletion (p<0.02), as compared to NMS-recipient controls (Figure 1C–F); each of these disease parameters also correlates with dengue severity in humans [15]–[17]. The gene discussed is TNF; the disease is dengue disease.