TNF and infection: While all mice treated with E60-hIgG1 succumbed to infection, lethality was completely prevented by a single 20 μg dose of E60-N297Q on day 1 (Figure 7B and data not shown), and E60-N297Q treatment significantly decreased viremia, tissue viral burden, and serum TNF-α levels as measured 3.5 days post-infection (Figure 7C and 7D, p<0.04).