Those cells are referred as tumor stem-like cells (TSLCs), and CD133 (also known as prominin-1 or AC133) has been considered as an important marker to enrich the stem-like population in tumors of various tissues, including those of the brain [2], prostate [3], pancreas [4], liver [5], colon [6,7], and skin for melanoma [8]. This evidence concerns the gene PROM1 and melanoma.