However, the overlap between this ~2.5 Mb region and the REPD to REPP interval contains only four single copy genes (Figure 3), of which neither PRAGMIN, CLDN23 (*OMIM 609203), MFHAS1 (OMIM *605352) nor ERI1 (OMIM *608739) are currently good candidates for heart disease. Here, PRAG1 is linked to heart disorder.