In an unselected U.S. cohort of patients diagnosed with tuberculosis, 45% lost weight and 20% had anorexia.23 Increased production of cytokines with lipolytic and proteolytic activity cause increased energy expenditure in tuberculosis.24 Leptin may also play an important role in wasting.25 In a study, malnutrition has been associated with atypical presentations of tuberculosis.26 Here, LEP is linked to tuberculosis.