In this study an apoptosis associated with a decrease of transferrin receptors and oxidative stress were induced by geoditin A in colon cancer HT29 cells, and this apoptosis was diminished by pre-treatment with oxidant scavenger, N-acetylcysteine, implicating the apoptosis inducing activity of geoditin A is mediated through oxidative stress. This evidence concerns the gene TFRC and colonic neoplasm.