ATP2A2 and Darier disease: Both Darier's disease and acrokeratosis verruciformis of Hopf are considered to be allelic to each other[1, 2] and are considered to be caused by separate defects in ATPA2 gene coding for SERCA 2.[3] Coexistence of both these conditions has been documented in the past.[4] It is still not known why mutations in the widely expressed SERCA2 can manifest as a focal skin disease without any other systemic involvement.