An immunosuppression due to the development of anti-ids to the ‘16/6 idiotype’ in about 50% of the patients also has been reported in SLE patients.[2] While in ITP cases, two types of idiotype effects were observed.[3] One was an immune suppression of disease due to the development of anti-idiotype, where 70% cases showed high levels of inhibitory anti-id antibodies and patients went into complete remission as compared to less than 5% cases showing a slight immune enhancement, where patients had lower levels of anti-ids. Here, IDS is linked to autoimmune thrombocytopenic purpura.