TSC1 and tuberous sclerosis: Tuberous sclerosis complex is a neurocutaneous syndrome involving multiple organ systems and shows extremely variable clinical manifestations.[3] The two genes, TSC-1 and TSC-2, involved in disease manifestations, are located on chromosomes 9 and 16, respectively.[4] Since these genes act as tumor suppressors, their mutation leads to hamartomatous lesions in various organs including the skin.