Because cyclosporine and anti-TNF-α agents, such as infliximab, adalimumab, and eternercept, are effective for psoriasis,[2] the trigger of keratinocytes hyperproliferation is presumed to be cellular immune response mediated by T cells and dendritic cells.[3] However, it is still unclear whether the keratinocytes derived from psoriasis are inherently distinct from normal keratinocytes. The gene discussed is TNF; the disease is psoriasis.