It has been co-administered with good effect, with methotrexate, in rheumatoid arthritis[35] and with thalidomide in Schnitzler's syndrome.[36] However, due to the dangers of drug interaction, with increased risk of neutropenia and serious infections, it is contraindicated with TNFα blockers (Infliximab, Etanercept, and Adalimumab). The gene discussed is TNF; the disease is rheumatoid arthritis.