Specific genes and their products (e.g., trabecular meshwork-inducible glucocorticoid response protein/myocilin [10-13], fibronectin [14], optineurin [15], procollagen C-proteinase enhancer 1 (PCOLCE1) [16], cytochrome P450 1B1 [17]) found in TM have been shown to play roles in glaucoma pathogenesis. The gene discussed is MYOC; the disease is glaucoma.