Two such connective tissue disorders are Marfan's syndrome and Congenital Contractural Arachnodactyly (CCA), which are caused by dominant mutations in the fibrillin-1 (FBN1) and fibrillin-2 (FBN2) genes respectively [1], [2]. The gene discussed is FBN1; the disease is congenital contractural arachnodactyly.