Notably, the median level of SOX2 protein was 8.2 and 39.7 higher in lung SCCs relative to adenocarcinomas when analyzed in TMA sets I and II, respectively (set I, adenocarcinoma, 30, SCC, 245; set II, adenocarcinoma 5.8, SCC, 230). Here, SOX2 is linked to adenocarcinoma.