Polymorphisms associated with risk of either ischemic stroke or myocardial ischemia but not the other disease type – i.e. dissociations: glycoprotein IIIa Leu33Pro conferring a risk for stroke, but not ischemic heart disease; PAI-1 4G- versus-5G associated positively with cardiac disease, but negatively with stroke, and angiotensinogen M235T posing a risk for coronary stenosis, but a trend for protection against stroke. The gene discussed is SERPINE1; the disease is Stroke.