platelets (glycoprotein IIIa), clotting (PAI-1) and blood pressure (angiotensinogen) - for which there also polymorphisms showing concordant disease effects, e.g. glycoprotein 1b-alpha, factor V Leiden and ACE, respectively – suggests that differences in risk-profile between ischemic heart disease and stroke cannot be attributed simply to a single pathophysiology e.g. hypertension. This evidence concerns the gene ACE and hypertensive disorder.