S100A8 and Granuloma: At 6 and 7 weeks p.i, S100A8 positive cells localised to the inner most zone of established granulomas, where inflammatory cells including neutrophils and macrophages are known to accumulate [4] (Figure 5b), and to the periphery of more mature granulomas adjacent to the fibrotic areas (Figure 5c) as confirmed by staining for collagen (Figure 5d).