Regarding FSCN1 regulation, several studies have reported that the actin-binding activity of fascin is inhibited by phosphorylation of residue Ser-39 by protein kinase Cα (Adams et al, 1999); β-catenin/T cell factor signalling transactivates the FSCN1 promoter in human colon carcinoma cell lines (Vignjevic et al, 2007); and FSCN1 down-regulation is associated with a decrease in β-catenin and c-erbB-2 expression (Xie et al, 2005). This evidence concerns the gene FSCN1 and colon carcinoma.