Therefore one may speculate that other E3 ligases may compensate for the loss of Nedd4-1 in some cell types (e.g., in MEFs as in Fouladkou et al., 2008) but not in others (e.g., in HEK293T and in the prostate cancer cell line DU-145, as in Wang et al., 2007), depending on the expression profile of Nedd4 family E3 ligases. The gene discussed is NEDD4; the disease is prostate cancer.