BRAF and central nervous system cancer: Moreover, IGFBP7 which acts through autocrine/paracrine pathways to inhibit BRAF-MEK-ERK signaling and induce apoptosis [9], but it is contradictory to some researcher's findings, as they indicated that IGFBP7 was highly overexpressed in glioma tissues, mediateing glioma cell growth, and migration [22].