VEGFA and osteosarcoma: Thus, anti-angiogenic therapy could augment the effects of adjuvant chemotherapy through the inhibition of VEGF, especially in elderly patients, in spinal or pelvic sites that are difficult to treat with wide surgery [6], and most of all, in "poor responders" to neoadjuvant chemotherapy, who are usually affected by the highest VEGF-positive osteosarcomas.