Different serum markers -- including sVCAM (677 [294 to 2,624] versus 512 [371 to 738] ng/mL; P = 0.018), YKL-40 (88 [24 to 256] versus 50 [15 to 59] ng/mL; P = 0.0029), and COMP (2.4 [1.2 to 4.4] versus 1.3 [0.8 to 1.5] μg/mL; P < 0.0001) -- were found to be significantly increased in RA patients as compared with healthy controls. This evidence concerns the gene COMP and rheumatoid arthritis.