Global cerebral ischemia following resuscitation resulted in a significant upregulation of cerebral tissue inflammatory cytokine mRNA expression (NT: IL-1β 8.7 ± 4.0, IL-6 4.3 ± 2.6, IL-10 2.5 ± 1.6, TNFα 2.8 ± 1.8, ICAM-1 4.0 ± 1.9-fold compared with sham control) and IL-1β protein concentration (1.9 ± 0.6-fold compared with sham control). The gene discussed is ICAM1; the disease is brain ischemia.