In our study on ROC analysis IL-6 performed good, with AUC 0.87, which is quite close to results of Groselj-Grenc [33] - AUC 0.776 for acute appendicitis diagnosis in children, and marginally different from results in Pavcnik-Arnol [16] study - AUC 0.67 for prediction of bacterial sepsis in neonates. The gene discussed is IL6; the disease is bacterial infectious disease with sepsis.