Seddon et al. [25] reported an ROC curve of 0.831 in a longitudinal study of progression to advanced AMD, using a model incorporating information on the genetic loci rs1061170 and rs1410996 in CFH; rs19490924 in ARMS2; rs9332739 in CC2; rs641153 in CFB; and rs2230199 in C3 in addition to the response to therapeutic supplementation. This evidence concerns the gene CFB and age-related macular degeneration.