Of note, this was only noticed inthe intermediate- and unfavorable-risk group and not in the favorable-riskgroup and the molecularly defined subset ‘NPM1 mutant without FLT3-ITD'.Multivariate analysis revealed p16INK4a, besides cytogeneticrisk-groups, as an independent prognostic parameter for overall survival (OS)in older (and not in younger) AML patients. This evidence concerns the gene CDKN2A and acute myeloid leukemia.