Thisanalysis revealed that in both sets the NF-κB cascade was up-regulated andthat maintenance of chromatin architecture, chromatin modification andorganelle organization were down-regulated [20, 28].Subsequently, comparison of gene expression profiles of AML samples of the 175youngest with the 175 oldest AML patients revealed that 477 probe sets wereup-regulated and 492 probe sets were down-regulated with increasing age at thesignificance level of P <1.0x10-5. This evidence concerns the gene NFKB1 and acute myeloid leukemia.