SIRT3 and kidney disorder: For example, in the rennin-angiotensin system,which plays a key role in the pathophysiology of cardiac and renal disease inhumans, targeted disruption of the angiotensin receptor (Agtr1agene in mice) yields animals with less cardiac and vascular injury, prolongedlifespan, increased number of mitochondria, and dramatic up-regulation of SIRT3in kidney tissue—a possible site of SIRT3 action that may contribute, at leastin part, to the phenotype that is observed [57].