CXCR2 and Insulin resistance: Moreover, CXCL5 is directly regulated byTNFα in both adipose tissue and macrophages by NFκB activation,suggesting that CXCL5 mediates the effects of TNFα in insulin resistance.Most importantly, inhibition of signaling from CXCR2, which is the CXCL5receptor, by injection of neutralizing anti-CXCL5 antibody or selectiveantagonist to CXCR2 in insulin-resistant-obese mice improves both insulinsensitivity and glucose clearance.