In the case of resveratrol, this includes SIRT1 activation,inhibition of cyclooxygenase and NFκB, induction of antioxidant enzymes,and activation of AMPK in vivo [13,44], in addition to the inhibitionof the leukemia-related kinases and S6K1 reported here (Supplementary Table 1). The gene discussed is RPS6KB1; the disease is leukemia.