MAPT and early-onset autosomal dominant Alzheimer disease: CK1 has alsobeen implicated in an aging-associated disease, namely Alzheimer's disease.Indeed, the expression of CK1 has been shown to be up-regulated in the brain ofAlzheimer patients [52,53], andCK1 has been implicated in the phosphorylation of the proteins tau andβ-secretase that have been linked to Alzheimer's disease [54,55].