PARP1 and Multiple Organ Failure: Parp1gene-disruption protected from tissue injury in various oxidativestress-related disease models ranging from stroke, (MPTP)-induced parkinsonism,myocardial infarction, streptozotocin-induced diabetes, lipopolysaccharide-inducedseptic shock, arthritis, to colitis and zymosan-induced multiple organ failure [7,73,112,113].There are striking similarities between the expression pattern of PARP1 and thedetrimental transcriptional activity of NF-κB.