The ability ofHPV E7 to up-regulate SIRT1 appears to be linked with HPV E7-mediatedsuppression of apoptosis in cervical cancer cells [30] since ourcurrent work also demonstrates that SIRT1 suppresses apoptosis in SiHa cells.In addition to up-regulating SIRT1 we show that HPV E7 induces globalsite-specific histone H3 modifications and, in synergy with the kinase auroraB, up-regulates the anti-apoptotic survivin protein. This evidence concerns the gene SIRT1 and cervical carcinoma.