Specifically we demonstrate (i) that exogenous expression of HPV E7 (butnot HPV E6) in primary human keratinocytes induces abnormally high levels ofthe SIRT1 protein, similar to those observed in human cervical cancer cells,and (ii) that HPV E7 (but not HPV E6) is required to maintain the abnormallyhigh levels of SIRT1 protein expressed in cervical cancer cells. The gene discussed is SIRT1; the disease is cervical carcinoma.