TP53 and cervical carcinoma: Indeed, the tumor suppressor p53 was first shown to beregulated by the ubiquitin-proteosome pathway by its association with thecellular ubiquitin ligase E6-AP, a protein upregulated by HPV E6 protein [3].High risk HPV genotypes (HPV16, -18, -31,  and -33) are now known as direct,causative agents of cervical cancer and the E6 and E7 proteins are widely knownto induce the degradation and downregulation of p53 and pRb, respectively, as amechanism for commendeering the growth of the host cell [4].