AD is also thought to have a local,non-immune mediated neuroinflammatory component with clusters of  activated  microglia,increased inflammatoryproteins (complementfactors, acute-phase protein, pro-inflammatory cytokines) [2-4], andincreased COX-1-expressing microglia surrounding amyloid plaques [2]. The gene discussed is PTGS1; the disease is Alzheimer disease.