ABCC3 and type 1 diabetes mellitus: In contrast, in the ileum of diabetic rats, there was no net flux of gliclazide and the unidirectional fluxes were much smaller than those seen in healthy animals, suggesting a modification of the activity of Mrp2 and Mrp3 in type 1 diabetes.40 In the present study we demonstrate that the treatment with probiotics modified the gliclazide fluxes in both healthy control and diabetic animals.