Knockdown of the anti-apoptotic Bcl-2 family member Myeloid Cell Leukaemia sequence 1 (Mcl-1) has been shown to sensitise Acute Lymphoblastic Leukaemia (ALL) cell lines to GC-induced apoptosis [31] and is also implicated in resistance to GC-induced apoptosis in human neutrophils [32]. The gene discussed is BCL2; the disease is acute lymphoblastic leukemia.