TBX5 and Holt-Oram syndrome: Mutations in human, TBX5 and TBX4, areassociated with Holt-Oram syndrome (HOS) (Basson et al.,1997; Li et al., 1997), and SmallPatella syndrome (SPS) (Bongers et al., 2004),respectively, and both syndromes are characterised by various limb defects in additionto other abnormalities.