MMP1 and head and neck squamous cell carcinoma: Hashimoto et al reported that the frequency of the MMP-1 2G/2G genotype was significantly higher in HNSCC patients than controls (140/223) (OR, 1.56, P = 0.042) and therefore concluded that the MMP-1 2G/2G genotype promoter polymorphism may be associated with HNSCC [44].