McColgan et al recently, analyzed the polymorphic association of MMP-1 (-1607 1G/2G), MMP-2 (1306C>T, 735 C>T), MMP-3 and MMP-9 susceptibility to cancer in 30,000 subjects (with lung, breast and colorectal carcinoma). Here, MMP1 is linked to colorectal carcinoma.