Park et al. used 2D-PAGE and MALDI-TOF mass spectrometry approach to analyze the proteome of anaplastic oligodendroglioma tissues, where peroxiredoxin 6 was identified to be overexpressed and later validated by Western blot and immunohistochemistry.[48] Khwaja et al. identified potential biomarkers in cerebrospinal fluid for central nervous system malignancies using MALDI analysis.[49] The study identified cystatin and carbonic anhydrase, which needs be further validated for its sensitivity and specificity. Here, CST4 is linked to oligodendroglioma.