For elucidating therapeutic biomarkers of angiogenesis in glioma, Mustafa et al. explored the proteome of glioma tumor vessels, which was microdissected by Laser Capture Microscopy.[2] The study employed nano-LC fractionation and MALDI-FTMS to identify the potential biomarkers including fibronectin and colligin 2. The gene discussed is FN1; the disease is glioma.