To explore this notion, we examined the effect of PLX4032 on primary melanoma cells, YULOVY isolated from a 1.38 mm primary cutaneous lesion and YUFULO ocular melanoma, both harboring the NRAS Q61L mutation, compared with melanocytes from a giant nevus (YUREEL-NV) and keratinocytes, all wild-type for BRAF and NRAS. The gene discussed is BRAF; the disease is ocular melanoma.