IL1B and rheumatoid arthritis: These miRNAshave been implicated in the biology of monocytic immune cells responding tolipopolysaccharide stimulation, human lung alveolar epithelial cell lineresponding to IL-1β induction, brain tissue from patients with Alzheimer'sdisease and synovial tissue from patients with rheumatoid arthritis [34,35,43,44].In the majority of these situations, miR-146a/b acts as a negative regulator ofinflammatory pathways.