Because overexpression of miR-146a/b in human MDA-MB-231 breast cancer cells, reduced thelevels of secreted IL-6 and IL-8 [41] andsince IRAK1 is a key mediator of the expression of IL-6 and IL-8, we comparedthe basal levels of secreted IL6 and IL8 in control and miR-146a/boverexpressing HCA2 cells. The gene discussed is IRAK1; the disease is breast carcinoma.