Current data from the COSMIC database, which summarises literature data and the ongoing Sanger cancer-genome project describes 29 K-Ras colorectal tumour mutations outwith codons 12, 13 and 61, and more than 11 800 mutations at these hotspot codons (http://www.sanger.ac.uk/genetics/CGP/), but does not describe associated phenotypes. This evidence concerns the gene KRAS and cancer.