A combined analysis involving genetic and crucial clinical/laboratory parameters (SGOT, SGPT, GGT, and alcohol consumed/day) indicated that the sub-group of AD patients with -141C Ins/Ins genotype (of -141C Ins/Del polymorphism) had significantly higher values (P < 0.01) of SGOT, SGPT, and GGT as compared to those with -141C Ins/Del and -141C Del/Del genotypes. This evidence concerns the gene GOT1 and Alzheimer disease.