Significant association of SNP -141C Ins/Del (P < 0.05; OR 0.19, 95%, CI 0.06-0.6) in DRD2 gene with alcohol dependence followed by categorical analysis suggesting -141C Ins allele to be predisposing to alcohol dependence in the present study is in conformity with findings of Konishi et al., which indicated that -141C Ins allele is a genetic risk factor for alcoholism in Mexican-Americans [36]. This evidence concerns the gene DRD2 and alcohol dependence.