ESR1 and carcinoma of esophagus: The effects of various doses of E2 on in vitro growth of these cell lines has established that one of the cell lines (ES-25C) showed significant inhibition at concentrations of 10-10 and 10-12 mol/l compared with the control, indicating a role for the oestrogen-ER system in growth inhibition of ER+ oesophageal cancer cell by oestradiol-17β [42,48]