In an attempt to further characterize this complex pattern of expression in human colorectal cancer cell lines and to assess its role in response to chemotherapy, the purpose of this paper was to analyze TAp73 mRNA and TAp73 protein expression in colorectal cancer cell lines treated with cetuximab and oxaliplatin, using Real Time PCR and Western Blot to explore associations between p73 expression and K-Ras/B-Raf status. This evidence concerns the gene TP73 and colorectal cancer.