The breast cancer FRR for relatives of HER2-positive cases was higher than for relatives of HER2-negative cases regardless of the age of the relative (2.02 (95% CI: 1.34 to 2.69) and 1.69 (95% CI: 1.46 to 1.92) respectively), but there was little statistical evidence for heterogeneity (P = 0.5). This evidence concerns the gene ERBB2 and breast carcinoma.